To assess patterns of sex chromosome divergence and recombination suppression, we compared coverage and SNP density differences between males and females within each species. Statistical methods for testing X chromosome variant associations: application to sex-specific characteristics of bipolar disorder.
Using this method, we have previously identified shared male-specific sequences between P. Test your knowledge.
In contrast, children who have extra numbered 1 to 22 chromosomes typically have severe abnormalities such as Down syndromewhich commonly results from a person having an extra chromosome Autosomal and sex chromosome disorders in McKinney, X chromosome dosage and dosage compensation may be relevant for polygenic complex traits, such as BD [ 9 ].
Genome-wide association study of 40, individuals identifies two novel loci associated with bipolar disorder. Length bp c. A condition is considered Y-linked if the mutated gene that causes the disorder is located on the Y chromosomeone of the two sex chromosomes in each of a male's cells.
Wright A. Related articles in Web of Science Google Scholar. Statistical methods for testing X chromosome variant associations: application to sex-specific characteristics of bipolar disorder.
Published by Oxford University Press. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. As this is not true when a SNP is in a region that is inactivated, an alternate approach is to treat all SNPs as subject to XCI, using an approach originally proposed by Clayton [ 30 ].
Front Genet. It is therefore possible that the presence of both sex chromosomes in a reference genome can cause technical artifacts in genomic data and affect downstream analyses and applications.